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Duloxetine: indications
Millions of people all over the globe live with depression, which affects all aspects of their lives including work and relations within their family. If left untreated, depression may cause severe psychiatric conditions. Some people even commit suicide on the ground of depression – that is why it is essential to start treating the disorder as soon as first signs appear.

If you have symptoms of depression, your doctor may advise to use Duloxetine – a medicament-antidepressant that belongs to the class of SSNRI. This med is mainly used for the treating of depression, but can also be used for the treating of general anxiety disorder, chronic pain disorder known under the name fibromyalgia and chronic muscle/joint pain as a result of osteoarthritis, for instance. The medicine is quite often prescribed for the treating of pain that is caused by nerve damage. This condition makes many diabetics suffer so much and is known under the name diabetic neuropathy.

Duloxetine: contraindications and precautions
Patients with an allergy to Duloxetine (active ingredient of the med) are contraindicated to use Duloxetine. You also should avoid using the medicine and seek for another treatment option in case you have uncontrolled glaucoma or are taking any of these MAO inhibitors:

  • tranylcypromine,
  • phenelzine,
  • linezolid,
  • selegiline,
  • furazolidone,
  • rasagiline,
  • isocarboxazid.

Before you decide to use Duloxetine, visit your healthcare professional to check whether you can safely use the med (or need special dosage) in case you have any of these conditions:

  • manic depression,
  • glaucoma,
  • hypertension,
  • epilepsy,
  • kidney disease,
  • blood clotting disorder,
  • a history of drug abuse,
  • any bleeding disease,
  • liver problems,
  • suicidal thoughts,
  • seizures.

Warn a medical professional if you are on the treatment with methylene blue injection.

Pregnant women should not use the medication without doctor’s approval. The med may harm a fetus if taken during the last trimester of pregnancy. If you breast-feed a baby, seek for safer treatment options as Duloxetine is dangerous for a baby and may pass to it through the breast milk. Or you can stop breast-feeding in order to start the treatment with Duloxetine.

Duloxetine: administration
Follow all the directions you received from your doctor. Never change your dose without consulting a medical specialist. If you feel you need a higher dose, discuss this issue with your healthcare provider. Bare in mind that your symptoms may start improving in a month after the treatment has been started.

Do not chew or break extended-release capsules – they should be swallowed whole. Do not drink alcohol as it may lead to liver damage.

Avoid overdosing. In case you overdose try to get emergency medical help.

Duloxetine: side effects
No matter whether you use Duloxetine or expensive branded drug, they have the same side effects. If a patient has signs of an allergy to the med, s/he should stop using it and appeal to medics asap.

Medical help may be needed in case severe side effect develop in a patient. These include:

  • trouble concentrating,
  • fast heart rate,
  • itching,
  • feeling unsteady,
  • sweating,
  • vomiting,
  • unusual bleeding,
  • overactive reflexes,
  • clay-colored stools,
  • upper stomach pain,
  • loss of coordination,
  • hallucinations,
  • high fever,
  • difficult urination (or urination with pain),
  • memory problems,
  • jaundice,
  • shallow breathing,
  • dark urine,
  • convulsions,
  • severe skin reactions and some other.

If you have symptoms that make you feel much discomfort, report this to your healthcare provider as well as if you or your family notice changes in your mood or behavior, for instance, if you’ve become restless, impulsive, more depressed, aggressive, anxious, hyperactive or irritable, if you have panic attacks, problems with sleeping or thoughts about suicide.

Dry mouth, mild nausea, constipation and drowsiness are most common side effects that are not serious and are not likely to cause much discomfort or cause harm to your health. You may continue using the med safely.

Duloxetine: drug interactions
Duloxetine may develop unsafe interactions with various drugs. That’s why before you use Duloxetine, get the full list of drugs it can interact with. It is known that Duloxetine can come into reaction (and affect the efficacy or increase risks of side effects) with the following medicaments: ciprofloxacin and some other antibiotics, diuretics, rizatriptan, cimetidine, tryptophan, zolmitriptan, lithium, almotriptan, tramadol, frovatriptan, fentanyl, St. John’s wort, buspirone, sumatriptan, warfarin and some other blood thinners, naratriptan, other antidepressant, including:

  • paroxetine,
  • fluoxetine,
  • desipramine,
  • fluvoxamine.

Tell your doctor of all other health products you are currently using before you start taking Duloxetine.

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