from $15.16 per tube

Retinoids are scientifically known as retinol palmitate and retinoic acid (its trans-isomers). Speaking simpler, it is a pure vitamin A.

Adapalene represents itself a connection that resembles a retinoid connection, but it is not a retinoid itself. Adapalene differs from a retinoid, as it does not interact with proteins of retinoids. Due to this fact, the differentiation of keratinocyte increases and a desquamation in sebaceous hair follicles is accelerated.

Its active action is connected with keratinization, providing an anti-inflammatory effect on the skin. Adapalene helps to fight with the first signs of acne – comedones.

One should apply Adapalene in cases of mild and moderate acne. Very often it is recommended to take antibiotics during the treatment process.

Results of application are felt after four or eight weeks after the start of treatment. However, noticeable improvement occurs only after three months of using the gel. However, sometimes you might need to repeat the treatment course in order to get rid of acne using this medication.

Adapalene: Recommended dosage and direction
The medication is designed for external use. It must be applied evenly in accordance with instructions. You should apply it directly on the area of the skin that has acne. One should use the cream only once a day, before going to bed.

Before you use Adapalene you should know how to apply it. You need to follow the following instructions:
1. Wash you face, but not with the contraindicated cleansers (those that dry skin). Then wash your face with foam or gel cleanser.
2. Wipe the face with a towel and wait from 5 to 15 minutes until the face becomes completely dry.
3. Apply a small amount of the medicine, so that it becomes not noticeable on the skin. Surpluses of the medicine can be removed with a napkin. Do not apply the gel on the eye area and lips. Do not apply the cream on the sunburnt areas, or damaged in other ways.
4. You can also apply a moisturizing cream or medicine, such as panthenol.

The medicine in form of a gel is suitable for oily skin, and the cream will be better for dry skin.

Adapalene: Precautions
You should not use Adapalene:

  • when the medicine (or adapalene) causes allergic reactions;
  • while taking retinoids (capsules with retinoid, beta-keratin);
  • during the use of creams that dry the skin (sulfur, zinc, salicylic acid, alcohol, abrasive soaps, peels, scrubs, etc.);
  • when the skin is damaged (cracks, wounds, eczema, burns, cancer, etc.);
  • during pregnancy.

Before pregnancy one should stop the use of medicine for a few months.

The drug can cause an acute skin reaction, but it is a completely normal reaction to this medicine. Such reactions are usually temporary and disappear within a short period of time.

If you experience a skin irritation, dryness or skin burns, you should stop using the cream for a day and reduce the dosage of the medication.

If the dryness appears constantly and causes severe anxiety, you should start using a moisturizer, such as Panthenol or Bepanten. If you are having only skin burns, you should apply only Panthenol.

If the reaction is very severe, the use of the drug should be discontinued.

Adapalene: Possible side effects
The drug has no serious side effects, except if you rub the medicine into the skin, there might be redness or peeling. Moreover, the drug is contraindicated during pregnancy and during breastfeeding. The cream should not get into the mouth and nasal cavity, eyes and other mucous membranes. In such cases, immediately wash the skin area with water of room temperature.

Most common side effects include the following:

  • redness;
  • peeling;
  • dryness;
  • burning sensation;
  • inflammation;
  • itching;
  • local muscle pain (only in case of strong overdose).

Furthermore, during the application of the medication one should not use cosmetics, as well as such that might dry skin (for example, it is better not to use an abrasive soap, peeling, scrubs, colognes and other alcohol-containing drugs). It is also undesirable to be in the sun or ultraviolet light for a long time, because there is a probability of additional unwanted irritation or redness. It is best to use a moisturizer with UV protection. You can find a special cream for protection against solar beams in the local pharmacy.

Drug interaction
Some people combine Adapalene use with other creams against acne. According to their observations, some skin products can soften the skin and remove the contents of the pores at the second day of use. Based on their recommendations, such a combination might be used when you have a large number of small comedones and moderate skin inflammation.

Dermatologists argue that such combination of skin products can make the skin thinner, and the number of capillaries will substantially increase.

The instruction of the drug says that one may use Adapalene with other skin products or medications that contain erythromycin. However, such combination is needed only in the cases, where the number of comedones is very large and there is mild inflammation of the skin elements. If inflammation of the skin is small, the use of additional medicaments is not necessary.

During any acne treatment, you should not apply skin products that contain extraneous chemicals. The drug is known to make the skin more sensitive. Consequently, the use of various irritants is undesirable. If there is no other option to hide the skin flaws, it is best to apply the makeup very carefully, and only one that will not harm the skin (there are special series of skin product for problematic skin).

Adapalene: Storage
As for storage, you should know that this drug is chemically inactive, but the temperature in its storage location should not be higher than usual room temperature.

see also:
Generic Revia
Generic Antabuse
Generic Retin-A
Generic Accutane